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This is why it's used in wound care and topical skincare products, and why researchers study it for connective tissue repair

The catalytically-active U2/U6 structure is formed during spliceosome activation on the central PRP8 scaffold with the assistance of activation-associated proteins such as CDC5L, PLRG1, RBM22, SKIP, and WBP11(NPW38BP) 12,18,19,100,101,102

A deficiency can occur for several reasons, such as pernicious anemia (a condition where the body cannot absorb vitamin B12 from the diet), certain medical conditions (e.g., Crohn's disease, celiac disease), surgical removal of part of the stomach or intestine, or strict vegetarian/vegan diets if not adequately supplemented

doi: 10.3389/fmed.2025.1644022 7 KcRShuklaSDGautamSSHansbroPMOTooleRF

The surgery can be open or endoscopic

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